now with 3500+ regions
Ancestry Reports

50+ reports
  • Ancestry Composition
  • Ancestry Detail Reports (48 reports)
  • Family Tree
  • Maternal Haplogroup
  • Paternal Haplogroup
  • Neanderthal Ancestry
See sample report - AncestrySee sample report - Ancestry

Trait Reports

30+ traits
  • Ability to Match Musical Pitch
  • Asparagus Odor Detection
  • Back Hair (available for men only)
  • Bald Spot (available for men only)
  • Bitter Taste
  • Bunions
  • Cheek Dimples
  • Cilantro Taste Aversion
  • Cleft Chin
  • Dandruff
  • Earlobe Type
  • Early Hair Loss (available for men only)
  • Earwax Type
  • Eye Color
  • Fear of Heights
  • Fear of Public Speaking
  • Finger Length Ratio
  • Flat Feet
  • Freckles
  • Hair Photobleaching (hair lightening from the sun)
  • Hair Texture
  • Hair Thickness
  • Ice Cream Flavor Preference
  • Light or Dark Hair
  • Misophonia (hatred of the sound of chewing)
  • Mosquito Bite Frequency
  • Motion Sickness
  • Newborn Hair
  • Photic Sneeze Reflex
  • Red Hair
  • Skin Pigmentation
  • Stretch Marks
  • Sweet vs. Salty
  • Toe Length Ratio
  • Unibrow
  • Wake-Up Time
  • Widow's Peak
See sample report - TraitsSee sample report - Traits

Health Predisposition Reports*

10+ reports
  • Type 2 Diabetes (Powered by 23andMe Research)
    Learn more about Type 2 Diabetes
    Genetic likelihood for a disorder of blood sugar regulation
    1,000+ variants in many genes; variants found in many ethnicities
  • Age-Related Macular Degeneration
    Genetic risk for a form of adult-onset vision loss
    2 variants in the ARMS2 and CFH genes; relevant for European descent
  • Alpha-1 Antitrypsin Deficiency
    Genetic risk for lung and liver disease
    2 variants in the SERPINA1 genes; relevant for European descent
  • BRCA1/BRCA2 (Selected Variants)
    Learn more about BRCA1/BRCA2 (Selected Variants)
    Genetic risk based on a limited set of variants for breast, ovarian, prostate and pancreatic cancer
    44 variants in the BRCA1 and BRCA2 genes; most relevant for Ashkenazi Jewish descent; does not include the majority of BRCA1/2 variants found in people of other ethnicities
  • Celiac Disease
    Genetic risk for gluten-related autoimmune disorder
    2 variants in the HLA-DQB1 and HLA-DQA1 genes; relevant for European descent
  • Chronic Kidney Disease (APOL1-Related)
    Genetic risk for a form of chronic kidney disease
    2 variants in the APOL1 genes; relevant for African descent
  • Familial Hypercholesterolemia
    Genetic risk for very high cholesterol, which can increase the risk for heart disease
    24 variants in the LDLR and APOB genes; relevant for European, Lebanese, Old Order Amish descent
  • G6PD Deficiency
    Genetic risk for a form of anemia
    2 variants in the G6PD genes; relevant for African, Southern European, Kurdish Jewish, Middle Eastern, Central Asian, South Asian descent
  • Hereditary Amyloidosis (TTR-Related)
    Genetic risk for a form of nerve and heart damage
    3 variants in the TTR genes; relevant for African American, West African, Portuguese, Brazilian, Northern Swedish, Japanese, Irish, British descent
  • Hereditary Hemochromatosis (HFE‑Related)
    Genetic risk for iron overload
    2 variants in the HFE genes; relevant for European descent
  • Hereditary Thrombophilia
    Genetic risk for harmful blood clots
    2 variants in the F2 and F5 genes; relevant for European descent
  • Late-Onset Alzheimer's Disease
    Genetic risk for a form of dementia
    1 variant in the APOE genes; variant found and studied in many ethnicities
  • MUTYH-Associated Polyposis
    Genetic risk for a specific colorectal cancer syndrome
    2 variants in the MUTYH genes; relevant for Northern European descent
  • Parkinson's Disease
    Genetic risk for a form of movement impairment
    2 variants in the LRRK2 and GBA genes; relevant for European, Ashkenazi Jewish, North African Berber descent
See sample report - Health PredispositionSee sample report - Health Predisposition

Wellness Reports

5+ reports
  • Alcohol Flush Reaction
  • Caffeine Consumption
  • Deep Sleep
  • Genetic Weight
  • Lactose Intolerance
  • Muscle Composition
  • Saturated Fat and Weight
  • Sleep Movement
See sample report - WellnessSee sample report - Wellness

Carrier Status Reports*

45+ reports
  • ARSACS
    1 variant in the SACS genes; relevant for French Canadian descent
  • Agenesis of the Corpus Callosum with Peripheral Neuropathy
    1 variant in the SLC12A6 genes; relevant for French Canadian descent
  • Autosomal Recessive Polycystic Kidney Disease
    3 variants in the PKHD1 genes
  • Beta Thalassemia and Related Hemoglobinopathies
    10 variants in the HBB genes; relevant for Sardinian, Cypriot, Italian/Sicilian, Greek descent
  • Bloom Syndrome
    1 variant in the BLM genes; relevant for Ashkenazi Jewish descent
  • Canavan Disease
    3 variants in the ASPA genes; relevant for Ashkenazi Jewish descent
  • Congenital Disorder of Glycosylation Type 1a (PMM2-CDG)
    2 variants in the PMM2 genes; relevant for Ashkenazi Jewish, Danish descent
  • Cystic Fibrosis
    29 variants in the CFTR genes; relevant for Ashkenazi Jewish, European, Hispanic/Latino descent
  • D-Bifunctional Protein Deficiency
    2 variants in the HSD17B4 genes
  • Dihydrolipoamide Dehydrogenase Deficiency
    1 variant in the DLD genes; relevant for Ashkenazi Jewish descent
  • Familial Dysautonomia
    1 variant in the ELP1 genes; relevant for Ashkenazi Jewish descent
  • Familial Hyperinsulinism (ABCC8-Related)
    3 variants in the ABCC8 genes; relevant for Ashkenazi Jewish descent
  • Familial Mediterranean Fever
    7 variants in the MEFV genes; relevant for Arab, Armenian, Sephardic Jewish, Turkish descent
  • Fanconi Anemia Group C
    3 variants in the FANCC genes; relevant for Ashkenazi Jewish descent
  • GRACILE Syndrome
    1 variant in the BCS1L genes; relevant for Finnish descent
  • Gaucher Disease Type 1
    3 variants in the GBA (also known as GBA1) genes; relevant for Ashkenazi Jewish descent
  • Glycogen Storage Disease Type Ia
    1 variant in the G6PC genes; relevant for Ashkenazi Jewish descent
  • Glycogen Storage Disease Type Ib
    2 variants in the SLC37A4 genes
  • Hereditary Fructose Intolerance
    4 variants in the ALDOB genes; relevant for European descent
  • Leigh Syndrome, French Canadian Type
    1 variant in the LRPPRC genes; relevant for French Canadian descent
  • Limb-Girdle Muscular Dystrophy Type 2D
    1 variant in the SGCA genes
  • Limb-Girdle Muscular Dystrophy Type 2E
    1 variant in the SGCB genes; relevant for Amish descent
  • Limb-Girdle Muscular Dystrophy Type 2I
    1 variant in the FKRP genes
  • MCAD Deficiency
    4 variants in the ACADM genes; relevant for European descent
  • Maple Syrup Urine Disease Type 1B
    2 variants in the BCKDHB genes; relevant for Ashkenazi Jewish descent
  • Mucolipidosis Type IV
    1 variant in the MCOLN1 genes; relevant for Ashkenazi Jewish descent
  • Neuronal Ceroid Lipofuscinosis (CLN5-Related)
    1 variant in the CLN5 genes; relevant for Finnish descent
  • Neuronal Ceroid Lipofuscinosis (PPT1-Related)
    3 variants in the PPT1 genes; relevant for Finnish descent
  • Niemann-Pick Disease Type A
    3 variants in the SMPD1 genes; relevant for Ashkenazi Jewish descent
  • Nijmegen Breakage Syndrome
    1 variant in the NBN genes
  • Nonsyndromic Hearing Loss and Deafness, DFNB1 (GJB2-Related)
    8 variants in the GJB2 genes; relevant for many ethnicities, including Ashkenazi Jewish, East/Southeast Asian, European, and Ghanaian descent. May also be relevant for Hispanic/Latino, Northern African/Middle Eastern, and South Asian descent
  • Pendred Syndrome and DFNB4 Hearing Loss (SLC26A4-Related)
    6 variants in the SLC26A4 genes
  • Phenylketonuria and Related Disorders
    23 variants in the PAH genes; relevant for Irish, Northern European descent
  • Pompe Disease
    5 variants in the GAA genes; relevant for African/African American descent; variants also common in European descent
  • Primary Hyperoxaluria Type 2
    1 variant in the GRHPR genes
  • Pyruvate Kinase Deficiency
    1 variant in the PKLR genes
  • Rhizomelic Chondrodysplasia Punctata Type 1
    1 variant in the PEX7 genes
  • Salla Disease
    1 variant in the SLC17A5 genes; relevant for Finnish, Swedish descent
  • Severe Junctional Epidermolysis Bullosa (LAMB3-Related)
    3 variants in the LAMB3 genes
  • Sickle Cell Anemia
    1 variant in the HBB genes; relevant for African, Middle Eastern, South Asian, Caribbean, Mediterranean, Central and South American descent
  • Sjögren-Larsson Syndrome
    1 variant in the ALDH3A2 genes; relevant for Swedish descent
  • Tay-Sachs Disease
    4 variants in the HEXA genes; relevant for Ashkenazi Jewish, Cajun descent
  • Tyrosinemia Type I
    4 variants in the FAH genes; relevant for French Canadian, Finnish descent
  • Usher Syndrome Type 1F
    1 variant in the PCDH15 genes; relevant for Ashkenazi Jewish descent
  • Usher Syndrome Type 3A
    1 variant in the CLRN1 genes; relevant for Ashkenazi Jewish descent
  • Zellweger Spectrum Disorder (PEX1-Related)
    1 variant in the PEX1 genes
See sample report - Carrier StatusSee sample report - Carrier Status

Pharmacogenetics Reports**

  • CYP2C19 Drug Metabolism*
    DNA variants that influence how the body processes certain medications for depression, acid reflux, heart disease and other conditions
  • DPYD Drug Metabolism*
    DNA variants that influence how the body processes certain cancer medications
  • SLCO1B1 Drug Transport*
    A DNA variant that influences how the body processes certain cholesterol-lowering medications

Health Predisposition Reports*

  • Hereditary Prostate Cancer (HOXB13-Related)
    A DNA variant that increases risk for prostate cancer
    1 variant in the HOXB13 genes; relevant for European (especially Northern European) descent
  • Anxiety (Powered by 23andMe Research)
    Genetic likelihood of developing anxiety that interferes with daily life
  • Asthma (Powered by 23andMe Research)
    Genetic likelihood of developing a chronic lung condition characterized by shortness of breath, wheezing, and coughing
  • Atrial Fibrillation (Powered by 23andMe Research)
    Genetic likelihood for a type of irregular heartbeat
  • Attention-Deficit/Hyperactivity Disorder (ADHD) (Powered by 23andMe Research)
    Genetic likelihood of having ADHD, which can be associated with differences in attention, memory, and managing thoughts or behaviors
  • Bipolar Disorder (Powered by 23andMe Research)
    Genetic likelihood of experiencing unusual shifts in mood, energy, activity, behavior, and sleep, beyond the normal ups and downs of life
  • Breast Cancer (available for females only) (Powered by 23andMe Research)
    Genetic likelihood of developing breast cancer
  • Colorectal Cancer (Powered by 23andMe Research)
    Genetic likelihood of developing cancer of the colon or rectum
  • Coronary Artery Disease (Powered by 23andMe Research)
    Genetic likelihood for a type of heart disease
  • Depression (Powered by 23andMe Research)
    Genetic likelihood of developing persistent low mood, loss of interest, and other symptoms that interfere with daily life
  • Diverticulitis (Powered by 23andMe Research)
    Genetic likelihood for a condition that occurs when small pouches in the digestive tract become inflamed
  • Eczema (Atopic Dermatitis) (Powered by 23andMe Research)
    Genetic likelihood for a skin condition characterized by dry, discolored, and itchy skin
  • Fibromyalgia (Powered by 23andMe Research)
    Genetic likelihood of developing a condition characterized by chronic pain and tenderness throughout the body
  • Gallstones (Powered by 23andMe Research)
    Genetic likelihood of developing solid, pebble-like masses that form in the gallbladder
  • Gestational Diabetes (available for females only) (Powered by 23andMe Research)
    Genetic likelihood of developing a type of diabetes that occurs during pregnancy
  • Glaucoma (Powered by 23andMe Research)
    Genetic likelihood of developing an eye condition that can cause partial vision loss and blindness
  • Gout (Powered by 23andMe Research)
    Genetic likelihood for a condition where one or more joints suddenly becomes painful and swollen
  • Hashimoto’s Disease (Powered by 23andMe Research)
    Genetic likelihood of developing an autoimmune condition in which the immune system causes damage to the thyroid gland
  • HDL Cholesterol (Powered by 23andMe Research)
    Genetic likelihood of developing low levels of HDL (“good”) cholesterol
  • High Blood Pressure (Powered by 23andMe Research)
    Genetic likelihood of developing high blood pressure
  • Insomnia (Powered by 23andMe Research)
    Genetic likelihood of developing a sleep disorder that causes chronic trouble with falling or staying asleep
  • Irritable Bowel Syndrome (Powered by 23andMe Research)
    Genetic likelihood of developing a chronic condition that impacts the large intestine
  • Kidney Stones (Powered by 23andMe Research)
    Genetic likelihood for solid, pebble-like masses that form in the kidneys
  • LDL Cholesterol (Powered by 23andMe Research)
    Genetic likelihood of developing high levels of LDL ("bad") cholesterol
  • Lupus (Powered by 23andMe Research)
    Genetic likelihood of developing a chronic autoimmune condition that can affect many parts of the body, such as the joints, skin, lungs, kidneys, and heart
  • Migraine (Powered by 23andMe Research)
    Genetic likelihood of experiencing migraine headaches
  • Nonalcoholic Fatty Liver Disease (Powered by 23andMe Research)
    Genetic likelihood for a condition where fat builds up in the liver
  • Obstructive Sleep Apnea (Powered by 23andMe Research)
    Genetic likelihood for a condition where breathing stops and starts repeatedly during sleep
  • Panic Attacks (Powered by 23andMe Research)
    Genetic likelihood of experiencing episodes of intense fear that last a few minutes to an hour
  • Polycystic Ovary Syndrome (PCOS) (available for females only) (Powered by 23andMe Research)
    Genetic likelihood for a hormone disorder that affects females
  • Preeclampsia (available for females only) (Powered by 23andMe Research)
    Genetic likelihood of developing persistent high blood pressure during pregnancy
  • Prostate Cancer (available for males only) (Powered by 23andMe Research)
    Genetic likelihood of developing cancer of the prostate, a male reproductive organ
  • Psoriasis (Powered by 23andMe Research)
    Genetic likelihood of developing an autoimmune condition that can cause itchy, discolored patches to form on the skin
  • Restless Legs Syndrome (Powered by 23andMe Research)
    Genetic likelihood for a condition characterized by an uncontrollable urge to move one's legs
  • Rosacea (Powered by 23andMe Research)
    Genetic likelihood for a chronic skin condition that often causes redness or visible blood vessels in the face
  • Severe Acne (Powered by 23andMe Research)
    Genetic likelihood for a skin condition characterized by many deep and painful types of pimples along with many whiteheads and blackheads
  • Skin Cancer (Basal and Squamous Cell Carcinomas) (Powered by 23andMe Research)
    Genetic likelihood of developing the two most common types of skin cancer
  • Skin Cancer (Melanoma) (Powered by 23andMe Research)
    Genetic likelihood of developing a common type of skin cancer
  • Triglycerides (Powered by 23andMe Research)
    Genetic likelihood of developing high levels of triglycerides (a type of lipid)
  • Uterine Fibroids (available for females only) (Powered by 23andMe Research)
    Genetic likelihood for a common type of non-cancerous growth in the uterus

Wellness Reports

  • Cat Allergy
  • Dog Allergy
  • Emotional Eating
  • Nearsightedness
  • Seasonal Allergies

Exome Sequencing Reports

6 reports (covering 55+ conditions ordered by a clinician)
  • Hereditary Cancer Report
    Coverage includes the following conditions:
    • APC-associated polyposis (Gene: APC)
    • ATM-associated cancers (Gene: ATM)
    • Juvenile polyposis syndrome (Gene: BMPR1A, SMAD4)
    • Hereditary breast and ovarian cancer (Gene: BRCA1, BRCA2)
    • CHEK2-associated cancers (Gene: CHEK2)
    • Hereditary prostate cancer (Gene: HOXB13)
    • Hereditary paraganglioma-pheochromocytoma syndrome (Gene: MAX, SDHAF2, SDHB, SDHC, SDHD, TMEM127)
    • Multiple endocrine neoplasia type 1 (Gene: MEN1)
    • Lynch syndrome (Gene: MLH1, MSH2, MSH6, PMS2)
    • MUTYH-associated polyposis (Gene: MUTYH)
    • NF2-related schwannomatosis (Gene: NF2)
    • Hereditary breast cancer (Gene: PALB2)
    • Polymerase proofreading-associated polyposis (Gene: POLD1, POLE)
    • PTEN hamartoma tumor syndrome (Gene: PTEN)
    • Retinoblastoma (Gene: RB1)
    • Familial medullary thyroid cancer (Gene: RET)
    • Multiple endocrine neoplasia type 2a (Gene: RET)
    • Multiple endocrine neoplasia type 2b (Gene: RET)
    • Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome (Gene: SMAD4)
    • Peutz-Jeghers syndrome (Gene: STK11)
    • Li-Fraumeni syndrome (Gene: TP53)
    • Tuberous sclerosis complex (Gene: TSC1, TSC2)
    • Von Hippel-Lindau syndrome (Gene: VHL)
    • Wilms tumor (Gene: WT1)
  • Hereditary Cardiovascular Disease Report
    Coverage includes the following conditions:
    • Familial thoracic aortic aneurysm and dissection (Gene: ACTA2, MYH11)
    • Familial hypertrophic cardiomyopathy (Gene: ACTC1, MYBPC3, MYH7, MYL2, MYL3, PRKAG2, TNNI3, TNNT2, TPM1)
    • Familial hypercholesterolemia (Gene: APOB, LDLR, LDLRAP1, PCSK9)
    • Type III hyperlipoproteinemia (Gene: APOE)
    • Dilated cardiomyopathy (Gene: BAG3, DES, FLNC, LMNA, MYH7, RBM20, SCN5A, TNNC1, TNNT2, TTN)
    • Myofibrillar myopathy (Gene: BAG3, DES, FLNC)
    • Long QT syndrome (Gene: CALM1, CALM2, CALM3, KCNH2, KCNQ1, SCN5A, TRDN)
    • Catecholaminergic polymorphic ventricular tachycardia (Gene: CALM1, CALM2, CALM3, CASQ2, RYR2, TRDN)
    • Ehlers-Danlos syndrome, vascular type (Gene: COL3A1)
    • Arrhythmogenic right ventricular cardiomyopathy (Gene: DSC2, DSG2, DSP, PKP2, TMEM43)
    • Dilated cardiomyopathy with wooly hair, palmoplantar keratoderma, and tooth agenesis (Gene: DSP)
    • Marfan syndrome (Gene: FBN1)
    • Brugada syndrome (Gene: SCN5A)
    • Loeys-Dietz syndrome (Gene: SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2)
  • Hereditary Metabolic Disease Report
    Coverage includes the following conditions:
    • Biotinidase deficiency (Gene: BTD)
    • G6PD deficiency (Gene: G6PD)
    • Pompe disease (Gene: GAA)
    • Fabry disease (Gene: GLA)
    • Maturity-onset diabetes of the young (Gene: HNF1A)
    • Ornithine carbamoyltransferase deficiency (Gene: OTC)
  • Hereditary Kidney Disease Report
    Coverage includes the following conditions:
    • APOL1-related chronic kidney disease (Gene: APOL1)
    • Autosomal dominant polycystic kidney disease (Gene: PKD1, PKD2)
  • Hereditary Neurological Disease Report
    Coverage includes the following conditions:
    • Alzheimer's disease (Gene: APOE)
    • Parkinson's disease (Gene: GBA, LRRK2)
  • Other Hereditary Conditions
    • Hereditary hemorrhagic telangiectasia (Gene: ACVRL1, ENG)
    • Wilson's disease (Gene: ATP7B)
    • Malignant hyperthermia (Gene: CACNA1S, RYR1)
    • Ehlers-Danlos syndrome, classic type (Gene: COL5A1, COL5A2)
    • Hereditary thrombophilia (Gene: F2, F5)
    • Hereditary hemochromatosis (Gene: HFE)
    • Leber congenital amaurosis (Gene: RPE65)
    • Retinitis pigmentosa (Gene: RPE65)
    • Alpha-1 antitrypsin deficiency (Gene: SERPINA1)
    • Hereditary transthyretin-related amyloidosis (Gene: TTR)

Blood Test Panels

55+ Biomarkers (initiated by a clinician)
  • Comprehensive Metabolic Panel
    • Blood Glucose
    • Blood Urea Nitrogen (BUN)
    • Creatinine
    • Blood Urea Nitrogen/Creatinine ratio (BUN/Cr)
    • Sodium
    • Potassium
    • Chloride
    • Bicarbonate (Carbon dioxide)
    • Calcium
    • Total Protein
    • Albumin
    • Globulin
    • Albumin/Globulin
    • Bilirubin
    • Alkaline phosphatase
    • Aspartate aminotransferase (AST)
    • Alanine aminotransferase (ALT)
    • Estimate Glomerular filtration rate (eGFR)
  • Complete Blood Count (CBC) Panel
    • White Blood Cell Count (WBC)
    • Red Blood Cell Count (RBC)
    • Hemoglobin
    • Hematocrit
    • Erythrocyte mean corpuscular volume (MCV)
    • Erythrocyte mean corpuscular hemoglobin (MCH)
    • Erythrocyte mean corpuscular hemoglobin concentration (MCHC)
    • Red Blood Cell distribution width (RDW)
    • Platelet Count
    • Neutrophil %
    • Neutrophil Count
    • Band Neutrophil %
    • Band Neutrophil Count
    • Metamyelocyte %
    • Metamyelocyte Count
    • Myelocyte %
    • Myelocyte Count
    • Promyelocyte %
    • Promyelocyte Count
    • Lymphocyte %
    • Lymphocyte Count
    • Variant Lymphocyte %
    • Monocyte %
    • Monocyte Count
    • Eosinophil %
    • Eosinophil Count
    • Basophil %
    • Basophil Count
    • Blast %
    • Blast Count
    • Nucleated Red Blood Cell %
    • Nucleated Red Blood Cell Count
    • Mean platelet volume (MPV)
  • Advanced Lipid Panel
    • Triglycerides
    • Total Cholesterol
    • HDL (High-Density Lipoprotein)
    • LDL (Low-Density Lipoprotein)
    • Total Cholesterol / HDL Mass Ratio
    • Non-HDL Cholesterol
    • Apolipoprotein B (ApoB) (one time only)
    • Lipoprotein (a) (Lp(a)) (one time only)
  • Endocrine Blood Tests
    • Thyroid-stimulating hormone (TSH) (one time only)
    • Hemoglobin A1c (HbA1c)

*The 23andMe PGS test includes health predisposition and carrier status reports. Health predisposition reports include both reports that meet FDA requirements for genetic health risks and reports which are based on 23andMe research and have not been reviewed by the FDA. The test uses qualitative genotyping to detect select clinically relevant variants in the genomic DNA of adults from saliva for the purpose of reporting and interpreting genetic health risks and reporting carrier status. It is not intended to diagnose any disease. Your ethnicity may affect the relevance of each report and how your genetic health risk results are interpreted. Each genetic health risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. The test is not intended to tell you anything about your current state of health, or to be used to make medical decisions, including whether or not you should take a medication, how much of a medication you should take, or determine any treatment. Our carrier status reports can be used to determine carrier status, but cannot determine if you have two copies of any genetic variant. These carrier reports are not intended to tell you anything about your risk for developing a disease in the future, the health of your fetus, or your newborn child's risk of developing a particular disease later in life. For certain conditions, we provide a single report that includes information on both carrier status and genetic health risk. Warnings & Limitations: The 23andMe PGS Genetic Health Risk Report for BRCA1/BRCA2 (Selected Variants) is indicated for reporting of 44 variants in the BRCA1 and BRCA2 genes. The report describes if a person's genetic result is associated with an increased risk of developing breast cancer and ovarian cancer and may be associated with an increased risk for prostate cancer, pancreatic cancer, and potentially other cancers. The variants included in this report do not represent the majority of the BRCA1/BRCA2 variants in people of most ethnicities. The MUTYH-Associated Polyposis Genetic Health Risk Report is indicated for reporting the Y179C and G396D variants in the MUTYH gene and an increased risk for colorectal cancer. The two variants included in this report are most common in people of Northern European descent. The Hereditary Prostate Cancer (HOXB13-Related) Genetic Health Risk report is indicated for reporting the G84E variant in the HOXB13 gene. The report describes if a person has the G84E variant and if a male is at increased risk for prostate cancer. The variant included in this report is most common in people of European descent, especially in people of Northern European descent. These reports do not include variants in other genes linked to hereditary cancers and the absence of variants included in this report does not rule out the presence of other genetic variants that may impact cancer risk. These reports are for over-the-counter use by adults, and provide genetic information to inform discussions with a healthcare professional. The PGS test is not a substitute for visits to a healthcare professional for recommended screenings or appropriate follow-up. Results should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. For important information and limitations regarding other genetic health risk reports and carrier status reports, visit 23andme.com/test-info/

**23andMe PGS Pharmacogenetics reports: The 23andMe test uses qualitative genotyping to detect 3 variants in the CYP2C19 gene, 2 variants in the DPYD gene and 1 variant in the SLCO1B1 gene in the genomic DNA of adults from saliva for the purpose of reporting and interpreting information about the processing of certain therapeutics to inform discussions with a healthcare professional. It does not describe if a person will or will not respond to a particular therapeutic. Our CYP2C19 Pharmacogenetics report provides certain information about variants associated with metabolism of some therapeutics and provides interpretive drug information regarding the potential effect of citalopram and clopidogrel therapy. Our SLCO1B1 Pharmacogenetics report provides certain information about variants associated with the processing of some therapeutics and provides interpretive drug information regarding the potential effect of simvastatin therapy. Our DPYD Pharmacogenetics report does not describe the association between detected variants and any specific therapeutic. Results for DPYD and certain CYP2C19 results should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. Warning: Test information should not be used to start, stop, or change any course of treatment and does not test for all possible variants that may affect metabolism or protein function. The PGS test is not a substitute for visits to a healthcare professional. Making changes to your current regimen can lead to harmful side effects or reduced intended benefits of your medication, therefore consult with your healthcare professional before taking any medical action. For important information and limitations regarding Pharmacogenetic reports, visit 23andme.com/test-info/pharmacogenetics/