23andMe Pharmacogenetics Reports:
What you should know

Pharmacogenetics reports tell you about DNA variants that may influence your body’s ability to process some medications. For example, our reports provide information about certain DNA variants that can affect how well specific drug-metabolizing enzymes work.

Some Pharmacogenetics reports also include Medication Insights, which tell you how certain variants may affect your response to specific medications.

  • Variant(s) not detected

    You do not have the variant(s) we tested. Keep in mind you may still have other DNA variants not included in this test that could affect how you process some medications.

  • Variant(s) detected

    You have one or more of the variant(s) we tested. The variant(s) may affect how your body processes certain medications. However, since many factors impact how medications are processed, the detected variant(s) may have no noticeable effect.

  • Result not determined

    Your test result could not be determined. This can be caused by random test error or other factors that interfere with the test.

    In very rare cases, we may not be able to interpret your genetic result. Talk to a healthcare professional to learn more about how DNA variants may influence your body’s ability to process medications.

In some cases, the laboratory may not be able to process your sample. If this happens, we will notify you by email and you may request one free replacement kit.

Other companies offering pharmacogenetic tests may include different DNA variants. This means that it’s possible to get different results using a test from a different company.

Do not use your results to start, stop, or change any course of treatment. Medications should always be taken as directed.

Talk to a healthcare professional about how DNA variants may influence your ability to process medications, or if you are concerned about your results.

Pharmacogenetic reports are intended to provide you with information that can inform conversations with a healthcare professional. These reports should not be used to make medical decisions. Results should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. Exceptions to this limitation are certain results from the CYP2C19 Drug Metabolism and SLCO1B1 Drug Transport reports, which do not require your physician to order confirmatory genetic testing.

Important Warnings and Limitations

Do not use your results to start, stop, or change any course of treatment. Medications should always be taken as directed. Making changes on your own can lead to harmful side effects or reduce the intended benefits of the medication.

Keep in mind that Pharmacogenetics reports

  • Do not replace discussions with a healthcare professional about the best course of treatment for you and cannot determine whether a medication is indicated for you.
  • Do not determine how you would respond to a particular medication.
  • Only provide Medication Insights about citalopram and clopidogrel (in the CYP2C19 Drug Metabolism report) and about simvastatin (in the SLCO1B1 Drug Transport report).
  • Do not diagnose any health conditions or tell you anything about your risk of developing any disease or condition.

Results from this test should not be used to make medical decisions. Results should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. Exceptions to this limitation are certain results from the CYP2C19 Drug Metabolism and SLCO1B1 Drug Transport reports, which do not require your physician to order confirmatory genetic testing.

What to know about: 

CYP2C19 Drug Metabolism

The CYP2C19 enzyme, often pronounced “sip-2-see-19”, helps the body process (or “metabolize”) certain medications. Specific DNA variants can affect how well the CYP2C19 enzyme works.

About this report

  • This report tests for DNA variants in the CYP2C19 gene that can affect the function of the CYP2C19 enzyme.
  • Altered CYP2C19 enzyme function may impact how well the body processes certain medications.

Non-genetic factors can also affect how your body processes medications

  • Age
  • Weight
  • Liver and kidney function
  • Other medications and dietary supplements
  • How well you follow instructions for use, which includes taking the right dose at the right time for the full course of treatment

View Frequently Asked Questions about this report here.

What do we test?

  • We test for three variants in the CYP2C19 gene: *2 (c.681G>A), *3 (c.636G>A), and *17 (c.-806C>T).
  • We do not test for all possible DNA variants that may affect the function of the CYP2C19 enzyme.

Warnings and Limitations

  • Do not use your results to start, stop, or change any course of treatment.
  • This test does not diagnose any health conditions, provide medical advice, or determine whether a medication is indicated for you.
  • This test does not account for lifestyle or other health factors that may affect the body’s ability to process medications.
  • This test only provides Medication Insights about citalopram and clopidogrel for certain genetic results.
  • The *3/*17 genotype result should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. For all other genotypes that result in a predicted metabolizer profile, confirmation is not required.

Test performance summary

  • Accuracy was determined by comparing results from this test with results from sequencing. Greater than 99% of test results were correct. While unlikely, this test may provide false positive or false negative results. For more details on the analytical performance of this test, refer to the package insert.
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