Your DNA might be the key to understanding lung cancer.

This is a research study focused on better understanding the genetics of people with lung cancer so that we can work to improve detection, risk reduction, and care. While research and targeted therapies have provided hope and progress for many, there’s still a lot we don’t know about the disease and its causes. Your help and participation in this study can change that.

23andMe scientists - with your help - are aiming to learn more about the genetics of people living with lung cancer to help improve care in the future. Right now, research and targeted therapies are making a difference for people who have lung cancer, but there is still much we don’t know about the disease and its causes. With your participation in this study, we hope to one day change that.

The 23andMe unique research platform enables a large group of individuals to come together to provide valuable data for scientists studying lung cancer. This research data includes Genetic Information (using DNA from saliva) and Self-Reported Information about each participant's unique experiences (using responses from online surveys), as well as, but not limited to, additional data sources such as medical records and tumor biomarker information.

We believe that this study will enhance research into lung cancer by:

• Bringing together a large group of people to better understand how genetics may influence lung cancer.
• Expanding the geographic reach of the research study by enabling participation from home.
• Removing some of the time and cost barriers that can slow progress in other types of studies.

Our goal for this study is to understand more about how our genetics influence lung cancer so that we can work to improve detection, risk reduction, and care. Ultimately, we want to help advance research toward finding a cure. Your participation is vital in helping us reach this important goal.

Our goal is to enroll 10,000 participants

We have a goal of recruiting 10,000 individuals diagnosed with lung cancer, with no restrictions on the type of lung cancer, stage of disease, age, gender, smoking status, biomarker, etc.

If you have been diagnosed with lung cancer, are over 18 years or older, and live in the United States, you may be eligible to join this study. To enroll, you will be asked to answer screening questions and complete study consents. At the end of the enrollment process, we will inform you if you are eligible to join the study.

1. Enroll

   The first step is to complete our enrollment process here. You will be asked a series of questions to confirm your eligibility and also be asked to sign research consent forms. After enrolling, you will be asked to take the first survey of the study.

2. Provide a saliva sample

   If you are new to 23andMe and are eligible to participate, you will register your 23andMe kit and provide a DNA sample (from your saliva) for genetic analysis. If you consent to storing your sample, we will securely store this saliva sample/DNA in our laboratory.

3. Surveys

   Initial participation involves completing an annual online survey through your 23andMe mobile app or the 23andMe website. After you complete your first survey, we will send you a yearly email with a link to the next survey.

   We are collecting this information over time so we can better understand your experience of living with lung cancer. You can choose whether to continue to participate or not at any time.

4. Additional Activities

   Throughout the study, we may also ask you to participate in additional activities, such as connecting your medical records or providing tumor biomarker information. This is completely optional, and we will email you to provide more information.

5. Sharing Your Research Information
   1. Your data will be shared with qualified research collaborators. This includes advocacy organizations, clinical and/or academic research centers, pharmaceutical companies, non-profit foundations, and patient registries for lung cancer research.
   2. Your data will also be shared in a scientific database controlled by a third party (not 23andMe) so that more researchers can make new discoveries to improve detection, risk reduction, and care.

This study will collect data in several forms. Participation involves completing an annual survey through your 23andMe mobile app or the 23andMe website. After you complete your first survey, we will send you a yearly email with a link to the next survey.

In addition to completing surveys, we may ask for your permission to link data from other sources such as, but not limited to, your medical records or tumor biomarker data. This additional data will supplement the data you provide to 23andMe and help qualified researchers enable earlier detection and advance research toward finding a cure in the future.

Being a 23andMe research participant means that you will agree to contribute your Genetic Information, Self-Reported Information, and data from other sources such as, but not limited to, your medical records or tumor biomarker data data, for research purposes. There are many aspects to being a research participant. We have summarized the most important ones on this page. If you have more questions, you can contact us at lung-cancer@23andme.com.

There is no compensation for participating in this study. New customers may receive the Health + Ancestry Service at no cost. Existing customers who are not on our most up-to-date genotyping platforms will be provided the opportunity to upgrade to our current genotyping platform at no cost. Existing customers who currently have access to the Ancestry Service will be given an opportunity to upgrade to the Health + Ancestry Service at no cost.

For important information and limitations regarding each genetic health risk and carrier status report included in our Health + Ancestry Service, visit Important test info

Please contact lung-cancer@23andme.com if you have additional questions.

• Your participation means that we will collect, store and share information about you. If 23andMe shares your Research Information with a scientific database or a qualified research collaborator, your data will be stored in various locations; this action cannot be undone and your data will not be returned to 23andMe. This may increase the risk of a security breach that could lead to the leak of your data. In the event of a breach, your information may become available to your employer, insurance company, or other individuals you did not want to inform. We believe the chance that someone could identify you is very small, but the risk may grow in the future if people come up with new ways of tracing information. There are currently laws that prevent your employer and health insurance provider from using your genetic information against you. However, these laws may not fully protect you in every situation.
• If you have not been previously genotyped on our platform and choose access to the 23andMe Ancestry Service, you may have an emotional response to learning new things about your genetics and ancestry.
• Please refer to our Terms of Service and Privacy Statement for more details about the risks of being genotyped.

This is a new opportunity to participate in lung cancer genetics research. As a research participant, you:

• Could play a role in helping researchers understand the relationship between the disease and genetics.
• Will be kept informed of the discovery process as research advances.
• Will have the option to learn more about your genetic health and ancestry.

If you agree to participate in the Lung Cancer Genetics Study, your participation includes the use of a 23andMe DNA kit and optional access to the 23andMe Service at no cost. As part of joining this study you will be required to agree to the 23andMe Terms of Service document.

We want to make sure you understand that while participating in the study activities described below, the following sections of the Terms of Service will not apply to the extent they prevent you from pursuing a claim if you suffer a study-related injury:

• Section 4 ("Indemnity")
• Section 4 ("Disclaimer of Warranties")
• Section 4 ("Limitation of Liability")
• Section 5(f) ("Term for Cause of Action")

Study activities include:

1. Providing a saliva sample for genetic analysis using a 23andMe DNA kit.
2. Initial participation involves completing up to four online surveys per year through your 23andMe mobile app or the 23andMe website. After you complete your first set of surveys, we will send you a yearly email with a link to the next set of surveys. You can choose whether to continue to participate or not at any time.
3. Additional Activities

   Throughout the study, we may also ask you to participate in additional activities, such as providing your medical records or tumor biomarker information. This is completely optional.

Please note, however, that if you choose to use any of 23andMe's products, software, services, and website, outside of your participation in these study activities, you will be, just like all users of 23andMe's products, software, services, and website, subject to the 23andMe Terms of Service.

Joining this study will not affect your diagnosis or treatment options today. Participation allows you to contribute to an effort to help advance lung cancer research in the future.

At this time, the 23andMe Health + Ancestry Service does not include a lung cancer-related health report.

At this time, enrollment in the Lung Cancer Genetics Study is limited to United States residents. We currently do not have plans to expand this study to residents of other countries.

Research projects like this must be carried out under the supervision of a research ethics committee. In the United States this is called an Institutional Review Board (IRB), which is an independent ethics panel that ensures research is conducted in accordance with government and ethical guidelines. 23andMe has approval from our IRB to conduct the Lung Cancer Genetics Study only in the United States, and therefore we are not authorized to enroll participants who live outside the United States at this time.

If you misplace your kit, don't worry. Email us at lung-cancer@23andme.com and we will mail you a new one at no cost. Once you're enrolled, we'll send you reminders to return your kit.

You can withdraw from research at any time by changing your consent status in your Account Settings. Email us at lung-cancer@23andme.com and we can help you.

We are here to answer your questions. Email us at lung-cancer@23andme.com and we will do our best to get back to you within two weeks.

As more people join this study and our research scientists start to look at the data, there may be an opportunity to participate in additional studies to enhance the research for lung cancer. For example, we may also ask you to complete short follow-up surveys regarding your experience with lung cancer over time.

If there are any additional study or survey opportunities, 23andMe's Health + Ancestry Service will let you know about them through your 23andMe.com account and/or email.

Research discoveries may lead to products or inventions that have value and can be sold by 23andMe or qualified research collaborators. If something like that happens, participants do not receive any financial benefits.

The Lung Cancer Genetics Study study is funded by support from the Troper Wojcicki Foundation.

Existing customers are customers who purchased a 23andMe kit prior to joining the study. We welcome any customer who wants to participate in this study, as long as they meet the eligibility criteria listed above and enroll in the study here

Existing customers who are not on our most up-to-date genotyping platforms will be provided the opportunity to upgrade to our current genotyping platform at no cost. Existing customers who currently have access to the Ancestry Service will be given an opportunity to upgrade to the Health + Ancestry Service at no cost. For important information and limitations regarding each genetic health risk and carrier status report included in our Health + Ancestry Service, visit Important test info.

No customers currently receive health reports on lung cancer.

New customers have not yet participated in 23andMe’s services and have not had their saliva analyzed prior to enrolling in a study. If they enroll in this study and meet the eligibility criteria, new customers will receive the 23andMe® Health + Ancestry Service, including a DNA test kit, at no cost. For important information and limitations regarding each genetic health risk and carrier status report included in our Health + Ancestry Service, visit Important test info.

23andMe Health + Ancestry Service offers over 150 personalized genetic reports on your health, traits and ancestry based on your DNA. You can learn more about this service at 23andMe.com.

If you are new to 23andMe, as part of your participation in this research study, you will receive complimentary access to 23andMe's Health + Ancestry Service. Learn more about the 23andMe Health + Ancestry Service here. For important information and limitations regarding each genetic health risk and carrier status report included in our Health + Ancestry Service, visit Important test info.

Existing 23andMe customers who are not on our most up-to-date genotyping platforms will be provided the opportunity to upgrade to our current genotyping platform at no cost. Existing customers who currently have access to the Ancestry Service will be given an opportunity to upgrade to the Health + Ancestry Service at no cost.

You will continue to have access to your 23andMe account and will receive report updates as long as the Genetic Information referenced in those updates is generated from your original DNA sample. If a future feature or report relies on DNA results not included in your initial analysis, you may need to purchase a chip upgrade and/or subscription to access that feature or report. Any future upgrades beyond the current technology are not included as a benefit to participation.

• 23andMe uses a range of physical, technical, and administrative procedures to protect the privacy of your Personal Information. Although 23andMe cannot provide a 100% guarantee that your data will be safe, 23andMe policies and procedures minimize the chance that a breach could take place.
• If 23andMe, our research collaborators, or future researchers publish data in a peer-reviewed journal, only data summaries, or combined data from many individuals, will be published.
• You can read more about our Privacy Statement and Security Measures here.
• Several laws at the federal and state levels help protect people against genetic discrimination. In particular, a federal law called the Genetic Information Nondiscrimination Act (GINA) is designed to protect people from this form of discrimination. This law makes it illegal for health insurance providers to use or require genetic information to make decisions about a person's insurance eligibility or coverage. It also makes it illegal for employers to use a person's genetic information when making decisions about hiring, promotion, and several other terms of employment. We will not provide any person’s data (genetic or non-genetic) to an insurance company or employer. GINA and other laws do not protect people from genetic discrimination in every circumstance.
• The third party controllers of the scientific database (not 23andMe) will take reasonable efforts to keep the information in the scientific database protected and secure. Data in the database will be individual-level Research Information (stripped of Registration Information), and encrypted when shared with approved researchers.